Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Teratogenicity01:07

Teratogenicity

4.5K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.5K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

4.0K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incidence and risk factors for fixation failure of femoral neck fractures in adults: a single-center multifactorial analysis.

Langenbeck's archives of surgery·2026
Same author

Development of a deep learning model for guiding treatment decisions of acute variceal bleeding in patients with cirrhosis.

World journal of gastroenterology·2025
Same author

Synthesis, optical properties, and two-photon bioimaging evaluation of novel fluorescent cationic molecules with symmetrical long conjugated all-<i>trans</i> structures.

Organic & biomolecular chemistry·2024
Same author

Effectiveness of Roy Adaptation Model-Based Cognitive Stimulation Therapy in Elderly Patients with Non-Small Cell Lung Cancer Undergoing Curative Resection.

The Tohoku journal of experimental medicine·2024
Same author

Accessory hepatic vein recanalization for Budd-Chiari syndrome: a systematic review and meta-analysis.

BMC gastroenterology·2023
Same author

Dietary Guanidine Acetic Acid Addition Improved Carcass Quality with Less Back-Fat Thickness and Remarkably Increased Meat Protein Deposition in Rapid-Growing Lambs Fed Different Forage Types.

Foods (Basel, Switzerland)·2023

Related Experiment Video

Updated: Mar 30, 2026

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
14:19

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction

Published on: June 29, 2013

28.8K

Routine screening for fetal limb abnormalities in the first trimester.

Yi-Mei Liao1, Sheng-li Li1, Guo-yang Luo2

  • 1Department of Ultrasound, Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, Guangdong, China.

Prenatal Diagnosis
|November 18, 2015
PubMed
Summary

First-trimester ultrasound accurately detects most fetal limb abnormalities, especially major defects. Early detection improves prenatal diagnosis and management of these congenital conditions.

More Related Videos

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings
14:40

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

Published on: October 25, 2015

9.9K
Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System
07:34

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

Published on: May 5, 2018

12.5K

Related Experiment Videos

Last Updated: Mar 30, 2026

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
14:19

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction

Published on: June 29, 2013

28.8K
Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings
14:40

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

Published on: October 25, 2015

9.9K
Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System
07:34

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

Published on: May 5, 2018

12.5K

Area of Science:

  • Medical Imaging
  • Prenatal Diagnosis
  • Fetal Medicine

Background:

  • Fetal limb abnormalities are a significant concern in prenatal care.
  • Early and accurate detection is crucial for appropriate management and counseling.
  • First-trimester ultrasonography offers a potential window for early identification.

Purpose of the Study:

  • To evaluate the diagnostic accuracy of first-trimester ultrasonography in detecting fetal limb abnormalities.
  • To compare the detection rates of limb abnormalities between the first and second trimesters.
  • To assess the types and incidence of fetal limb abnormalities identified in early pregnancy.

Main Methods:

  • Retrospective analysis of 9438 fetuses undergoing first-trimester nuchal translucency (NT) assessment and detailed fetal anatomy survey.
  • Comparison of limb abnormality detection between first and second trimester scans.
  • Confirmation of diagnoses through delivery or autopsy records.

Main Results:

  • The incidence of fetal limb abnormalities was 0.38% (36/9438).
  • Prenatal diagnosis was achieved in 77.8% (28/36) of cases.
  • First-trimester scans identified 63.9% (23/28) of detectable limb abnormalities, with limb reduction defects being most common.

Conclusions:

  • First-trimester ultrasonography is effective in identifying the majority of fetal limb abnormalities, particularly major defects.
  • Early detection in the first trimester aids in timely prenatal diagnosis and management planning.
  • Larger studies are warranted to further validate these findings and expand the understanding of early limb anomaly detection.