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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
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Pregnancy and Lupus Nephritis
Andrea G Kattah1, Vesna D Garovic2
1Department of General Internal Medicine, Mayo Clinic, Rochester, MN.
Seminars in Nephrology
|November 18, 2015
Summary
Managing lupus nephritis during pregnancy is challenging due to physiological changes that increase risks for mothers and babies. Delaying conception until remission and close monitoring by a multidisciplinary team are crucial for optimal outcomes.
Area of Science:
- Immunology
- Nephrology
- Obstetrics
Background:
- Pregnancy induces significant physiological and immunological changes, increasing risks for patients with lupus nephritis.
- Lupus nephritis flares during pregnancy can lead to adverse maternal and fetal outcomes, including preeclampsia, fetal loss, and preterm delivery.
Purpose of the Study:
- To outline the challenges and best practices for managing lupus nephritis in pregnant patients.
- To emphasize the importance of multidisciplinary care and medication management during pregnancy.
Main Methods:
- Review of current literature on lupus nephritis management in pregnancy.
- Discussion of physiological changes during pregnancy impacting lupus nephritis.
- Highlighting the role of interdisciplinary teams in patient care.
Main Results:
- Pregnancy poses a high risk for lupus nephritis disease activity and adverse outcomes.
- Optimal pregnancy outcomes are associated with conception during disease remission.
- Close monitoring of maternal disease activity and fetal well-being is essential.
Conclusions:
- Effective management requires delaying conception until lupus nephritis is in remission.
- An interdisciplinary team approach involving obstetricians, rheumatologists, and nephrologists is critical.
- Careful consideration of medication safety, including dosing and teratogenicity, is paramount.
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