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Updated: Mar 30, 2026

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients
Published on: April 18, 2025
Personalizing blood pressure management in septic shock
Ryotaro Kato1, Michael R Pinsky2
1Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA, 15261, USA. ryotarokato@gmail.com.
Targeting mean arterial pressure (MAP) in sepsis resuscitation requires individualized approaches. For sepsis patients without hypertension, aim for 65-70 mmHg, while those with chronic hypertension may benefit from 80-85 mmHg.
Area of Science:
- Critical Care Medicine
- Hemodynamics
- Sepsis Pathophysiology
Background:
- Sepsis resuscitation involves optimizing hemodynamic parameters.
- Mean arterial pressure (MAP) is a key indicator of perfusion but requires careful interpretation.
Purpose of the Study:
- To review evidence for specific mean arterial pressure (MAP) targets during sepsis resuscitation.
- To guide individualized MAP targets based on patient characteristics and organ perfusion needs.
Main Methods:
- Systematic review of clinical data on MAP targeting in sepsis.
- Analysis of organ-specific perfusion pressure requirements.
Main Results:
- A MAP of 65-70 mmHg is a reasonable initial target for sepsis patients without chronic hypertension.
- Higher MAP targets (80-85 mmHg) may reduce renal injury in hypertensive patients but increase arrhythmia risk.
- MAP alone is insufficient for assessing organ perfusion, especially with elevated intracranial, intra-abdominal, or tissue pressures.
Conclusions:
- Individualized MAP targets are crucial in sepsis resuscitation.
- Organ-specific perfusion pressures (e.g., brain, renal, splanchnic) should guide MAP titration.
- MAP should be adjusted based on organ function and tissue perfusion measures beyond a general target.
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