Related Experiment Video
Updated: Mar 30, 2026
22:06
Induction and Monitoring of Adoptive Delayed-Type Hypersensitivity in Rats
Published on: October 1, 2007
12.4K
[Anticonvulsant Hypersensitivity Syndrome: A Case Report]
Felipe Valderrama Escudero1, Laura Elisa Montoya González2
1Médico psiquiatra, Profesor vinculado en pregrado y posgrado, Universidad CES, Medellín, Colombia.
Revista Colombiana De Psiquiatria
|November 18, 2015
Summary
DRESS syndrome, a severe drug reaction, can manifest with rash and organ issues. This case highlights valproic acid
Area of Science:
- Pharmacology
- Toxicology
- Dermatology
Context:
- DRESS syndrome (drug reaction with eosinophilia and systemic symptoms) is a severe idiosyncratic drug reaction.
- It presents with rash, fever, lymphadenopathy, and internal organ dysfunction.
- Diagnosis is often challenging and by exclusion.
Purpose:
- To report a case of DRESS syndrome in a patient with bipolar affective disorder.
- To highlight the potential role of valproic acid in triggering DRESS syndrome.
- To emphasize the diagnostic challenges and potential severity of DRESS syndrome.
Summary:
- A patient with bipolar affective disorder developed a systemic inflammatory response potentially linked to valproic acid.
- Symptoms were exacerbated when valproic acid was used with other drugs acting via different mechanisms.
- The case underscores the difficulty in diagnosing DRESS syndrome, which can be fatal.
Impact:
- This case report emphasizes the importance of considering DRESS syndrome in patients presenting with systemic inflammation and rash.
- It highlights the potential contribution of valproic acid and drug interactions to DRESS syndrome development.
- Early recognition and diagnosis are crucial for managing this potentially life-threatening condition.
