Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Cyberbullying and Suicidal Behavior: What is the Connection? About a Case].

Revista colombiana de psiquiatria·2017
Same author

[Integrated management of patients with schizophrenia: beyond psychotropic drugs].

Revista colombiana de psiquiatria·2016
Same author

[Sensitivity and specificity between the Composite International Diagnostic Interview Version 3.0 (World Mental Health, CIDI) and the Standardised Clinical Evaluation version I (SCID-I) in a mental health survey of the city of Medellin, 2012].

Revista colombiana de psiquiatria·2016
Same author

[Intervention of Schizophrenia From the Community Model].

Revista colombiana de psiquiatria·2016

Related Experiment Video

Updated: Mar 30, 2026

Induction and Monitoring of Adoptive Delayed-Type Hypersensitivity in Rats
22:06

Induction and Monitoring of Adoptive Delayed-Type Hypersensitivity in Rats

Published on: October 1, 2007

12.4K

[Anticonvulsant Hypersensitivity Syndrome: A Case Report].

Felipe Valderrama Escudero1, Laura Elisa Montoya González2

  • 1Médico psiquiatra, Profesor vinculado en pregrado y posgrado, Universidad CES, Medellín, Colombia.

Revista Colombiana De Psiquiatria
|November 18, 2015
PubMed
Summary

DRESS syndrome, a severe drug reaction, can manifest with rash and organ issues. This case highlights valproic acid

Keywords:
Bipolar disorderDisfunción hepáticaHepatic dysfunctionTrastorno afectivo bipolarValproic acidÁcido valproico

More Related Videos

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

25.1K
Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

16.8K

Related Experiment Videos

Last Updated: Mar 30, 2026

Induction and Monitoring of Adoptive Delayed-Type Hypersensitivity in Rats
22:06

Induction and Monitoring of Adoptive Delayed-Type Hypersensitivity in Rats

Published on: October 1, 2007

12.4K
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

25.1K
Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

16.8K

Area of Science:

  • Pharmacology
  • Toxicology
  • Dermatology

Context:

  • DRESS syndrome (drug reaction with eosinophilia and systemic symptoms) is a severe idiosyncratic drug reaction.
  • It presents with rash, fever, lymphadenopathy, and internal organ dysfunction.
  • Diagnosis is often challenging and by exclusion.

Purpose:

  • To report a case of DRESS syndrome in a patient with bipolar affective disorder.
  • To highlight the potential role of valproic acid in triggering DRESS syndrome.
  • To emphasize the diagnostic challenges and potential severity of DRESS syndrome.

Summary:

  • A patient with bipolar affective disorder developed a systemic inflammatory response potentially linked to valproic acid.
  • Symptoms were exacerbated when valproic acid was used with other drugs acting via different mechanisms.
  • The case underscores the difficulty in diagnosing DRESS syndrome, which can be fatal.

Impact:

  • This case report emphasizes the importance of considering DRESS syndrome in patients presenting with systemic inflammation and rash.
  • It highlights the potential contribution of valproic acid and drug interactions to DRESS syndrome development.
  • Early recognition and diagnosis are crucial for managing this potentially life-threatening condition.