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Updated: Mar 30, 2026

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
Published on: May 28, 2019
[Thromboaspiration in the treatment of ST segment elevation myocardial infarction]
C Brasselet1, S Duval1, M Leroux1
1Unité de cardiologie interventionnelle, polyclinique Courlancy, 38, rue de Courlancy, 51000 Reims, France.
Insights
Routine manual thrombectomy for acute myocardial infarction shows mixed results. While initially promising, current evidence does not support its routine use due to increased stroke risk and lack of mortality benefit.
Area of Science:
- Cardiology
- Interventional Cardiology
- Acute Myocardial Infarction Treatment
Background:
- Routine manual thrombectomy during primary percutaneous coronary intervention (PCI) has been debated for acute myocardial infarction (AMI).
- Early studies suggested benefits like improved ST-segment elevation and reduced distal embolization, with TAPAS trial showing reduced mortality.
Observation:
- Later research failed to consistently replicate these positive findings.
- Thrombectomy was associated with an increased risk of stroke.
- Current guidelines advise against routine thrombectomy prior to primary angioplasty.
Findings:
- Evidence does not support routine manual thrombectomy to decrease cardiovascular mortality, recurrent myocardial infarction, cardiogenic shock, or severe heart failure.
- The procedure carries an increased risk of stroke.
Implications:
- Further research is needed to identify specific patient subgroups who may benefit from thrombectomy.
- Optimal techniques, pharmacological settings, and endpoint criteria for manual thrombectomy require precise definition.
- Despite scientific downgrading, interest in thrombectomy persists among interventional cardiologists.
Abstract:
Routine manual thrombectomy during primary percutaneous coronary intervention might be intuitively justified. While older registers reported contradictory results, interventional cardiologists remained interested in using such devices during the mechanical treatment of acute myocardial infarction. The first studies were congruent to demonstrate a significant relationship between thromboaspiration and significant improvement of ST-segment elevation, lower distal embolization, despite TAPAS was the only to significantly reduce the mortality. Later studies were unable to confirm these promising data, avoiding routine manual thrombectomy prior to primary angioplasty to decrease cardiovascular mortality, recurrent myocardial infarction, cardiogenic shock or severe heart failure. Moreover, thrombectomy was associated with an increased rate of stroke. Should thrombectomy therefore be conclusively overlooked? It is presumably required to define which patient is eligible for thrombectomy, to define how to perfectly perform manual thrombectomy, to specify how to gently move towards the thrombus, the optimal pharmacological environment, the number of aspirations and the criterion to stop or to repeat aspiration. Indeed, while thrombectomy is nowadays scientifically downgraded, it remains of potential interest in numerous interventional cardiologists.
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