Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fluid Mosaic Model01:19

Fluid Mosaic Model

19.8K
Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich...
19.8K
Mechanisms of Membrane Domain Formation00:59

Mechanisms of Membrane Domain Formation

4.4K
Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
Another mechanism for membrane domain formation involves membrane proteins interacting with...
4.4K
Multi-pass Transmembrane Proteins and β-barrels01:09

Multi-pass Transmembrane Proteins and β-barrels

6.8K
In multi-pass transmembrane proteins, the polypeptide chain crosses the membrane more than once. The transmembrane polypeptide chain either forms an α-helix or β-strand structure. α-Helix containing multi-pass transmembrane proteins are ubiquitous, whereas β-strand containing ones are mainly found in gram-negative bacteria, mitochondria, and chloroplasts.
α-Helix containing multi-pass transmembrane proteins
Multi-pass transmembrane proteins such as...
6.8K
Mechanisms of Membrane-bending01:15

Mechanisms of Membrane-bending

3.7K
The living membranes are flexible due to their fluid mosaic nature; however, their bending into different shapes is an active process regulated by specific lipids and proteins. The membrane bending can be transient as seen in vesicles or stable for a long time as in microvilli. Cells regulate the size, location, and duration of the membrane curvature.
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
3.7K
Membrane Fluidity01:23

Membrane Fluidity

179.3K
Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
179.3K
Membrane Fluidity01:26

Membrane Fluidity

17.9K
Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is...
17.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling.

Immunity·2026
Same author

Toward Lab-Ready AI Synthesis Plans with Protection Strategies and Route Scoring.

Journal of chemical information and modeling·2026
Same author

Genomic sequencing of multicystic mesothelioma finds cohesin complex mutations associated with disease recurrence in patients referred for cytoreductive surgery and HIPEC.

British journal of cancer·2026
Same author

Democratising real-world drug discovery through agentic AI.

Drug discovery today·2026
Same author

SMARTS-RX: a SMARTS-based representation of chemical functions for reactivity analysis.

Journal of cheminformatics·2025
Same author

From concept to chemistry: integrating protection group strategy and reaction feasibility into non-natural amino acid synthesis planning.

Chemical science·2025

Related Experiment Video

Updated: Mar 30, 2026

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

3.4K

A simple and transferable all-atom/coarse-grained hybrid model to study membrane processes.

Samuel Genheden1, Jonathan W Essex1

  • 1School of Chemistry, University of Southampton, Highfield , SO17 1BJ, Southampton, United Kingdom.

Journal of Chemical Theory and Computation
|November 18, 2015
PubMed
Summary

This study introduces an efficient hybrid model for simulating membrane processes. The novel approach enhances computational speed and accuracy for studying peptides and small molecules in membranes.

More Related Videos

A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics
10:31

A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics

Published on: September 2, 2020

8.2K
Automated Lipid Bilayer Membrane Formation Using a Polydimethylsiloxane Thin Film
08:23

Automated Lipid Bilayer Membrane Formation Using a Polydimethylsiloxane Thin Film

Published on: July 10, 2016

19.2K

Related Experiment Videos

Last Updated: Mar 30, 2026

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

3.4K
A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics
10:31

A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics

Published on: September 2, 2020

8.2K
Automated Lipid Bilayer Membrane Formation Using a Polydimethylsiloxane Thin Film
08:23

Automated Lipid Bilayer Membrane Formation Using a Polydimethylsiloxane Thin Film

Published on: July 10, 2016

19.2K

Area of Science:

  • Computational chemistry
  • Biophysics
  • Molecular dynamics

Background:

  • Studying membrane processes requires accurate and efficient computational models.
  • Existing models may face limitations in speed or complexity.

Purpose of the Study:

  • To develop and validate an efficient all-atom/coarse-grained hybrid model for membrane simulations.
  • To apply the model to investigate the behavior of peptides within model membranes.

Main Methods:

  • Implemented a multiple-time step integrator for improved efficiency.
  • Fine-tuned atom-bead interactions using potential of mean force calculations.
  • Validated the model using small-molecule partition coefficients.

Main Results:

  • The hybrid model demonstrated efficiency and accuracy in membrane simulations.
  • Successfully studied the tilt angles of Walp23 and Kalp23 helices.
  • Assessed the stability of the glycophorin A dimer in different membrane environments.

Conclusions:

  • The developed model offers a novel, simple, and efficient approach for studying membrane processes.
  • It avoids complex additions like extra particles or tabulated potentials.
  • The model is suitable for diverse applications in membrane biophysics.