Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does thyroid function influence serum beta 2-microglobulin?

H Mulder, H R Fischer

    The Netherlands Journal of Medicine
    |April 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type 2 diabetes aetiology.

    Nature metabolism·2024
    Same author

    MicroRNA 29 modulates β-cell mitochondrial metabolism and insulin secretion via underlying miR-29-OXPHOS complex pathways.

    Acta physiologica (Oxford, England)·2024
    Same author

    Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants.

    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry·2021
    Same author

    Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion.

    Molecular metabolism·2021
    Same author

    [Guideline 'Organ donation following euthanasia"].

    Nederlands tijdschrift voor geneeskunde·2017
    Same author

    Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes.

    Nature communications·2017
    Same journal

    A diagnostic tool for self-poisoned patients: Analysis of gastric content and lavage fluids.

    The Netherlands journal of medicine·2020
    Same journal

    Answer to Photoquiz A bone disorder with skin lesions.

    The Netherlands journal of medicine·2020
    Same journal

    A bone disorder with skin lesions.

    The Netherlands journal of medicine·2020
    Same journal

    Answer to Photoquiz A fascinating liver abscess.

    The Netherlands journal of medicine·2020
    Same journal

    A fascinating liver abscess.

    The Netherlands journal of medicine·2020
    Same journal

    Answer to Photoquiz A polyposis syndrome.

    The Netherlands journal of medicine·2020
    See all related articles

    Serum beta 2-microglobulin (beta 2-m) levels decreased in hyperthyroid patients treated with carbimazole, suggesting its immunosuppressive role. Hypothyroid patients showed normal beta 2-m levels, unaffected by levothyroxine treatment.

    Area of Science:

    • Endocrinology
    • Immunology

    Background:

    • Elevated serum beta 2-microglobulin (beta 2-m) is observed in hyperthyroidism.
    • The role of T-lymphocytes and carbimazole's mechanism in hyperthyroidism require further elucidation.

    Purpose of the Study:

    • To investigate serum beta 2-m levels in hyperthyroid and hypothyroid patients.
    • To assess the effect of carbimazole and levothyroxine on beta 2-m levels.
    • To explore the potential immunosuppressive action of carbimazole on T-lymphocytes.

    Main Methods:

    • Serum beta 2-m levels were measured in 24 hyperthyroid patients (Graves' disease, toxic nodular goitre) and 7 hypothyroid patients.
    • Measurements were taken before and during 6 weeks of treatment with carbimazole (hyperthyroid) or levothyroxine (hypothyroid).

    Related Experiment Videos

    Main Results:

    • Initially elevated beta 2-m levels in 16 hyperthyroid patients normalized with carbimazole treatment.
    • Hypothyroid patients had normal beta 2-m levels, with a slight decline during levothyroxine substitution.
    • These findings support carbimazole's immunosuppressive effect on T-lymphocytes in hyperthyroidism.

    Conclusions:

    • Carbimazole treatment normalizes elevated serum beta 2-m in hyperthyroidism, indicating an immunosuppressive effect on T-lymphocytes.
    • Thyroid hormone levels are not the primary cause of increased serum beta 2-m in hyperthyroidism.
    • Further research supports carbimazole's immunomodulatory role in Graves' disease and toxic nodular goitre.