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Published on: February 27, 2014
Meat intake and risk of inflammatory bowel disease: A meta-analysis
Jian Ge1, Tian Jie Han, Jin Liu
1Department of Gastroenterology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China; These authors contributed to this work equally. 15168866758@163.com.
Background/Aims:
This meta-analysis is designed to determine the association between meat consumption and the risk of inflammatory bowel disease.
Materials And Methods:
Search relevant literature published in PubMed, Cochrane before July 2015 without restrictions. Studies were included if relative ratios and the corresponding 95% confidence intervals of the risk of inflammatory bowel disease were reported with respect to meat consumption.
Results:
Nine studies were included in this meta-analysis. Relative to those who did not or seldom eat meat, meat consumers had a significantly greater risk of inflammatory bowel disease (pooled relative ratio: 1.50, 95% confidence interval: 1.15-1.95). The funnel plot revealed no evidence for publication bias.
Conclusion:
Meat consumption may increase the risk of inflammatory bowel disease. Additional large prospective studies are warranted to verify this association.
Insights
Meat consumption is linked to a higher risk of developing inflammatory bowel disease (IBD). This meta-analysis suggests a significant association, highlighting the need for further research into this dietary link.
Area of Science:
- Gastroenterology
- Nutritional Epidemiology
Background:
- Inflammatory bowel disease (IBD) encompasses chronic conditions like Crohn's disease and ulcerative colitis.
- Dietary factors are increasingly recognized as potential contributors to IBD pathogenesis.
Purpose of the Study:
- To conduct a meta-analysis evaluating the association between meat consumption and the risk of inflammatory bowel disease (IBD).
Main Methods:
- A systematic literature search was performed in PubMed and Cochrane databases up to July 2015.
- Included studies reported relative ratios and 95% confidence intervals for IBD risk related to meat intake.
- Nine studies were synthesized for the meta-analysis.
Main Results:
- Meat consumers exhibited a significantly elevated risk of IBD compared to non-consumers (pooled relative ratio: 1.50, 95% CI: 1.15-1.95).
- No evidence of publication bias was detected through funnel plot analysis.
Conclusions:
- Findings suggest that meat consumption may be associated with an increased risk of inflammatory bowel disease (IBD).
- Further large-scale prospective studies are recommended to confirm this association and elucidate underlying mechanisms.
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