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Aneurysmal bone cysts: a clinicopathological study of 105 cases
Cancer
|May 1, 1977
Summary
Aneurysmal bone cysts recur in 30.5% of cases, with incomplete surgical removal being a major factor. High mitotic index also correlates with increased recurrence, suggesting more radical treatment for high-risk patients.
Area of Science:
- Orthopedic Pathology
- Surgical Oncology
- Bone Tumors
Background:
- Aneurysmal bone cysts (ABCs) are benign but locally aggressive bone lesions.
- Understanding recurrence factors is crucial for effective management.
Purpose of the Study:
- To analyze clinicopathological features of 105 aneurysmal bone cyst cases.
- To identify factors influencing recurrence rates.
- To evaluate treatment strategies based on risk factors.
Main Methods:
- Clinicopathological review of 105 aneurysmal bone cyst cases.
- Analysis of age, sex, localization, and treatment methods.
- Assessment of recurrence rates in relation to surgical completeness and mitotic index.
Main Results:
- Overall recurrence rate of 30.5%; 34.2% for curettage.
- Incomplete surgical removal led to recurrence in 70.6% of cases.
- Significantly higher recurrence (P<0.01) with mitotic index ≥7/50 fields.
- No significant difference in recurrence based on age groups, age/size combination, or localization.
Conclusions:
- Incomplete surgical removal is a key predictor of aneurysmal bone cyst recurrence.
- High mitotic index indicates a higher risk of recurrence.
- Radical treatment, such as cryosurgery, is recommended for high-risk patients.