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Nitrofurantoin: an update
1Infectious Disease Division, Winthrop-University Hospital, Mineola, New York.
Obstetrical & Gynecological Survey
|May 1, 1989
Summary
Nitrofurantoin is a long-standing antibiotic for treating urinary tract infections (UTIs). It remains a safe and effective option, especially for recurrent UTIs and in obstetrics, due to its lack of resistance development.
Area of Science:
- Pharmacology
- Infectious Diseases
- Urology
Background:
- Nitrofurantoin has over 35 years of clinical use for urinary tract infections (UTIs).
- It is utilized for acute uncomplicated UTIs, recurrent UTIs, and asymptomatic bacteriuria in pregnancy.
- Its application extends to prophylaxis and treatment of nosocomial infections linked to urinary tract instrumentation.
Purpose of the Study:
- To highlight the continued relevance and efficacy of nitrofurantoin in managing various urinary tract infections.
- To emphasize its favorable safety profile and lack of R-factor resistance.
- To discuss its "rediscovery" in obstetrics and gynecology for UTIs.
Main Methods:
- Review of clinical use and established efficacy of nitrofurantoin.
- Analysis of safety records and resistance patterns.
- Comparison with newer antimicrobial agents.
Main Results:
- Nitrofurantoin demonstrates a sustained safety record over decades of use.
- It has not shown associated R-factor resistance, a significant advantage.
- It is increasingly recognized for its utility in obstetrics and gynecology for UTIs.
Conclusions:
- Nitrofurantoin remains a valuable therapeutic option for a range of urinary tract infections.
- Its established safety and lack of resistance make it a preferred choice, particularly in specific patient populations.
- The drug's enduring clinical utility warrants its consideration in current treatment guidelines for UTIs.