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NEREC, an effective brain mapping protocol for combined language and long-term memory functions.

Marcela Perrone-Bertolotti1, Cléa Girard1, Emilie Cousin2

  • 1Univ. Grenoble Alpes, LPNC, F-38040 Grenoble, France; CNRS, LPNC UMR 5105, F-38040 Grenoble, France.

Epilepsy & Behavior : E&B
|November 18, 2015
PubMed
Summary

A new fMRI protocol, NEREC, effectively maps temporoparietal language and memory networks in healthy adults. This combined task approach shows robust activation, proving its suitability for evaluating cognitive functions in temporal lobe epilepsy patients.

Keywords:
EncodingHippocampusLanguageMemoryNamingRetrievalTemporal

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Functional Neuroimaging

Background:

  • Temporal lobe epilepsy (TLE) can impact language and memory processing networks.
  • Existing experimental designs struggle to effectively engage temporoparietal networks in healthy subjects.
  • A robust protocol is needed to assess these networks for clinical applications in TLE.

Purpose of the Study:

  • To develop and validate a novel experimental paradigm, NEREC, for robustly mapping temporoparietal language and long-term memory networks.
  • To demonstrate the protocol's effectiveness in healthy subjects using functional magnetic resonance imaging (fMRI).
  • To establish a feasible tool for clinical evaluation of cognitive functions in TLE patients.

Main Methods:

  • Developed the NEREC protocol with two runs: a combined language-memory encoding task (NE) and a memory retrieval task (REC).
  • Utilized fMRI in healthy subjects to measure brain activation during NE (naming and encoding) and REC (recognition).
  • Modified stimulus modality between NE (nonverbal) and REC (verbal) to enhance memory retrieval and hippocampal activation.

Main Results:

  • The NE task revealed temporoparietal activation linked to lexico-semantic language processes and memory encoding/retrieval.
  • Encoding activated the left hippocampus, bilateral fusiform, and inferior temporal gyri.
  • Recognition (recollection) activated the right hippocampus and predominantly left fusiform gyrus.

Conclusions:

  • The novel NEREC protocol successfully combines language and memory tasks to reveal robust temporoparietal network activation in healthy individuals.
  • NEREC demonstrates feasibility and suitability for clinical evaluation of language and memory functions, particularly in patients with TLE.
  • This protocol offers a unique approach to double-map networks involved in naming, memory encoding, and retrieval, focusing on hippocampal and lateral temporal cortex engagement.