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Related Concept Videos

Genomics02:02

Genomics

41.7K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

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Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
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Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Related Experiment Video

Updated: Mar 30, 2026

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
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Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

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Identification of potential COPD genes based on multi-omics data at the functional level.

Zhe Liu1, Wan Li, Junjie Lv

  • 1College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China. chenlina@ems.hrbmu.edu.cn.

Molecular Biosystems
|November 18, 2015
PubMed
Summary

Researchers identified 102 potential genes for chronic obstructive pulmonary disease (COPD) using a novel multi-omics approach. This method integrates methylation, microRNA, and mRNA data to improve early diagnostics and therapeutic development for COPD.

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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

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Area of Science:

  • Genomics
  • Bioinformatics
  • Pulmonology

Background:

  • Chronic obstructive pulmonary disease (COPD) is a complex respiratory disease characterized by multi-omics dysfunctions.
  • Altered biological processes including cell adhesion, signaling, and proliferation contribute to COPD pathogenesis.

Purpose of the Study:

  • To introduce a novel systematic approach, Methylation-MicroRNA-MRNA-GO (MMMG), for identifying potential COPD-associated genes.
  • To integrate multi-omics data (methylation, microRNA, mRNA) with functional information to uncover COPD genetic factors.

Main Methods:

  • The MMMG approach was developed to analyze integrated multi-omics profiles and functional information.
  • Gene identification involved analyzing methylation, microRNA expression, and mRNA expression datasets.

Main Results:

  • The MMMG method identified 8 co-functional gene classes and 102 potential COPD genes.
  • These genes demonstrated high accuracy in classifying COPD patients and healthy individuals.
  • Identified genes and pathways were validated through correlation coefficients, literature review, and independent datasets.

Conclusions:

  • The MMMG approach effectively identifies potential COPD genes by analyzing multi-omics data at a functional level.
  • The identified genes offer insights into COPD's genetic landscape, potentially improving early diagnosis and therapeutic strategies.