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Updated: Mar 30, 2026

An R-Based Landscape Validation of a Competing Risk Model
Published on: September 16, 2022
Bayes and empirical Bayes methods for reduced rank regression models in matched case-control studies
Jaya M Satagopan1, Ananda Sen2, Qin Zhou1
1Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York 10017, U.S.A.
Abstract:
Matched case-control studies are popular designs used in epidemiology for assessing the effects of exposures on binary traits. Modern studies increasingly enjoy the ability to examine a large number of exposures in a comprehensive manner. However, several risk factors often tend to be related in a nontrivial way, undermining efforts to identify the risk factors using standard analytic methods due to inflated type-I errors and possible masking of effects. Epidemiologists often use data reduction techniques by grouping the prognostic factors using a thematic approach, with themes deriving from biological considerations. We propose shrinkage-type estimators based on Bayesian penalization methods to estimate the effects of the risk factors using these themes. The properties of the estimators are examined using extensive simulations. The methodology is illustrated using data from a matched case-control study of polychlorinated biphenyls in relation to the etiology of non-Hodgkin's lymphoma.
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