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miR-382 inhibits migration and invasion by targeting ROR1 through regulating EMT in ovarian cancer

Hong Tan1, Qingnan He2, Guanhui Gong3

  • 1Department of Pathology, School of Basic Medical Science, Central South University, Changsha, Hunan 410013, P.R. China.

International Journal of Oncology
|November 18, 2015
PubMed

Insights

MicroRNA-382 (miR-382) is downregulated in ovarian cancer, inhibiting cell proliferation and metastasis. It targets ROR1, suppressing migration and invasion by regulating epithelial-mesenchymal transition (EMT).

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are crucial in cancer development.
  • Reduced miR-382 expression is noted in several cancers.
  • The role of miR-382 in ovarian cancer remains unclear.

Purpose of the Study:

  • To investigate the function of miR-382 in ovarian cancer.
  • To identify the molecular targets of miR-382 in this context.

Main Methods:

  • Analysis of miR-382 expression in ovarian cancer tissues and cell lines.
  • Assessment of miR-382's effects on ovarian cancer cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT).
  • Identification and validation of ROR1 as a direct target of miR-382.

Main Results:

  • miR-382 expression was significantly downregulated in human ovarian cancer tissues and cell lines.
  • Overexpression of miR-382 suppressed ovarian cancer cell proliferation, migration, invasion, and EMT.
  • Receptor tyrosine kinase orphan receptor 1 (ROR1) was identified as a direct target of miR-382.
  • miR-382 counteracted ROR1's pro-migratory, pro-invasive, and EMT-promoting effects.

Conclusions:

  • miR-382 functions as a tumor suppressor in ovarian cancer.
  • miR-382 inhibits ovarian cancer cell migration and invasion by targeting ROR1 and regulating EMT.
  • miR-382 represents a potential therapeutic target for ovarian cancer.

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