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Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
Published on: February 16, 2015
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The quest for spatio-temporal control of CAR T cells
Jie Sun1,2, Michel Sadelain1,2
1Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Cell Research
|November 18, 2015
Abstract:
Chimeric antigen receptors (CARs) are synthetic receptors capable of directing potent antigen-specific anti-tumor T cell responses. A recent report by Wu et al. extends a series of strategies aiming to curb excessive T cell activity, utilizing in this instance a chemical dimerizer to aggregate antigen-binding, T cell-activating and costimulatory domains.
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