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Chronic Stress Facilitates the Development of Deep Venous Thrombosis

Tao Dong1, Yu-Wen Cheng1, Fei Yang2

  • 1Department of Physiology, Medical College of Soochow University, Suzhou 215003, China.

Oxidative Medicine and Cellular Longevity
|November 18, 2015
PubMed

Insights

Chronic stress promotes deep venous thrombosis (DVT) via renal sympathetic nerves and oxidative stress. Treatments like renal sympathetic denervation or antioxidants can alleviate DVT development and platelet activation.

Area of Science:

  • Cardiovascular Science
  • Neuroscience
  • Physiology

Background:

  • Modern social stress exacerbates cardiovascular diseases, including deep venous thrombosis (DVT).
  • Renal sympathetic denervation is a treatment for resistant hypertension.
  • Oxidative stress is closely linked to cardiovascular disease development.

Purpose of the Study:

  • To investigate the mechanisms linking the renal sympathetic nerve system and oxidative stress to blood coagulation in DVT.
  • To explore the role of these factors in DVT development under chronic stress conditions.

Main Methods:

  • A chronic foot shock model in rats was used to simulate physiological stress.
  • Deep venous thrombosis (DVT) and platelet aggregation were assessed.
  • Effects of renal sympathetic denervation and antioxidant (Tempol) treatment were evaluated.
  • Circulating oxidation factors were measured.

Main Results:

  • Chronic foot shock promoted DVT, likely through platelet aggregation.
  • Renal sympathetic denervation and Tempol treatment alleviated DVT aggravation and platelet activation.
  • Denervation reduced circulating oxidation factors.

Conclusions:

  • Both renal sympathetic nerve activity and oxidative stress contribute to DVT development under chronic stress.
  • These findings suggest potential novel therapeutic strategies for clinical DVT patients.

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