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Related Experiment Videos

Acromegaly in an infant.

D L Blumberg1, C A Sklar, R David

  • 1Department of Pediatrics, New York University Medical Center, NY 10016.

Pediatrics
|June 1, 1989
PubMed
Summary

This study reports on the youngest known case of acromegaly in a child with a growth hormone-secreting pituitary adenoma. Post-surgery, hyperprolactinemia may have sustained normal growth by stimulating somatomedin C.

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Area of Science:

  • Pediatric Endocrinology
  • Neuroendocrinology
  • Oncology

Background:

  • Growth hormone-secreting pituitary adenomas are rare in children.
  • Acromegaly, caused by excess growth hormone, typically presents later in life.
  • Hyperprolactinemia can coexist with growth hormone-secreting tumors.

Observation:

  • A 21-month-old girl presented with macrocephaly and rapid growth, diagnosed with acromegaly.
  • Preoperative hormone levels showed significantly elevated growth hormone, somatomedin C, and prolactin.
  • Tumor resection revealed a growth hormone-secreting adenoma without prolactin production.

Findings:

  • Postoperatively, growth hormone levels normalized, and growth velocity returned to normal.
  • Somatomedin C levels normalized, while prolactin remained moderately elevated.
  • Sustained normal growth post-surgery suggests hyperprolactinemia's role in stimulating somatomedin C.

Implications:

  • This case highlights the youngest documented instance of childhood acromegaly.
  • It suggests a potential role for hyperprolactinemia in maintaining growth despite low growth hormone post-treatment.
  • Further research is needed to understand the interplay between growth hormone, prolactin, and somatomedin C in pediatric growth disorders.

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