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[Ageing: a matter of heart?]

Jeanne Mialet-Perez1, Victorine Douin-Echinard1, Daniel Cussac1

  • 1Inserm, UMR1048, institut des maladies métaboliques et cardiovasculaires, 1, avenue Jean Poulhès, BP 84225, 31432 Toulouse cedex 4, France - Université Paul Sabatier, Toulouse, France.

Medecine Sciences : M/S
|November 19, 2015
PubMed

Insights

Ageing accelerates heart failure by promoting cellular senescence in heart cells. This review explores mechanisms like telomere dysfunction and mitochondrial impairment in cardiac ageing.

Area of Science:

  • Cardiovascular Biology
  • Gerontology
  • Cellular Senescence

Background:

  • Ageing is a primary risk factor for chronic diseases, with heart failure being significantly impacted.
  • Pathological ageing and heart failure are closely intertwined, potentially accelerating each other.

Purpose of the Study:

  • To review the mechanisms underlying normal and premature senescence in cardiomyocytes and cardiac stromal cells.
  • To elucidate the role of key factors in cardiac ageing and failure.

Main Methods:

  • Literature review of recent findings on cellular senescence in the heart.
  • Analysis of molecular mechanisms contributing to cardiac ageing.

Main Results:

  • Senescence of cardiomyocytes and cardiac stromal cells contributes to heart failure.
  • Telomere dysfunction, DNA damage, mitochondrial impairment, miRNAs, and the senescent cell secretome are key players.

Conclusions:

  • Cellular senescence is a critical mechanism in cardiac ageing and the development of heart failure.
  • Understanding these mechanisms can inform therapeutic strategies for age-related heart disease.

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