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Crosstalk between transforming growth factor-β signaling pathway and long non-coding RNAs in cancer

Jianbo Wang1, Na Shao2, Xiaowen Ding3

  • 1Department of Radiation, Qilu Hospital of Shandong University, Jinan, China.

Cancer Letters
|November 19, 2015
PubMed

Insights

The transforming growth factor-beta (TGF-β) pathway and long non-coding RNAs (lncRNAs) interact in cancer. Understanding this network is key for developing new cancer prevention and treatment strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The transforming growth factor-beta (TGF-β) signaling pathway is implicated in cancer development, acting as either a tumor suppressor or promoter.
  • Long non-coding RNAs (lncRNAs) are critical regulators of cellular processes and have emerged as key players in various cancers.

Purpose of the Study:

  • To review the intricate network between the TGF-β signaling pathway and lncRNAs in the context of cancer.
  • To summarize recent advancements in understanding how this crosstalk influences tumorigenesis.

Main Methods:

  • Literature review of recent studies focusing on the TGF-β pathway and lncRNAs in cancer.
  • Analysis of identified interactions where lncRNAs target TGF-β pathway members.
  • Examination of studies showing TGF-β-induced lncRNA production.

Main Results:

  • Evidence indicates a significant crosstalk between the TGF-β pathway and lncRNAs in cancer.
  • Several TGF-β pathway components are directly targeted by lncRNAs.
  • TGF-β signaling can induce the expression of numerous lncRNAs, suggesting a feedback mechanism.

Conclusions:

  • The TGF-β pathway and lncRNA network plays a crucial role in regulating cancer development.
  • Further investigation of this network holds potential for novel strategies in cancer prevention and treatment.
  • A deeper understanding of this molecular interplay is essential for advancing oncology therapeutics.
Keywords:
CancerLong non-coding RNAsTransforming growth factor-β

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