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Hypodontia in the beagle after perinatal whole-body 60Co gamma irradiation
A C Lee1, G M Angleton, S A Benjamin
1Department of Radiology, College of Veterinary Medicine, Colorado State University, Fort Collins 80523.
Radiation Research
|June 1, 1989
Abstract:
As part of a long-term study to evaluate health effects of pre- and postnatal irradiation, dental development was examined. Beagles were irradiated in utero at 8, 28, or 55 days postcoitus or postnatally at 2, 70, or 365 days postpartum. Whole-body 60Co gamma radiation doses ranged from 0 to 3.8 Gy. There was an age-dependent dose-related increase in premolar hypodontia for animals irradiated at 55 days postcoitus or 2 days postpartum with doses of 0.83 Gy or higher and for those irradiated at 28 days postcoitus with 1.2 Gy or higher.