Related Experiment Video
Updated: Mar 30, 2026

Measuring Axonal Cargo Transport in Mouse Primary Cortical Cultured Neurons
Published on: February 24, 2023
Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders
Dick Jaarsma1, Casper C Hoogenraad2
1Department of Neuroscience, Erasmus MC Rotterdam, Netherlands.
Abstract:
The Golgi apparatus is a dynamic organelle involved in processing and sorting of lipids and proteins. In neurons, the Golgi apparatus is important for the development of axons and dendrites and maintenance of their highly complex polarized morphology. The motor protein complex cytoplasmic dynein has an important role in Golgi apparatus positioning and function. Together, with dynactin and other regulatory factors it drives microtubule minus-end directed motility of Golgi membranes. Inhibition of dynein results in fragmentation and dispersion of the Golgi ribbon in the neuronal cell body, resembling the Golgi abnormalities observed in some neurodegenerative disorders, in particular motor neuron diseases. Mutations in dynein and its regulatory factors, including the dynactin subunit p150Glued, BICD2 and Lis-1, are associated with several human nervous system disorders, including cortical malformation and motor neuropathy. Here we review the role of dynein and its regulatory factors in Golgi function and positioning, and the potential role of dynein malfunction in causing Golgi apparatus abnormalities in nervous system disorders.
More Related Videos
Related Concept Videos
Microtubule Associated Motor Proteins
The Movement of Organelles and Vesicles
Mechanism of Ciliary Motion
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
Lysosomal Hydrolases
Transport Across the Golgi
Golgi Matrix Proteins
One of the first identified Golgi matrix proteins was GM130, a rod-like protein located in the cis-Golgi. Subsequently, many Golgi...

