Hypothalamic control of brown adipose tissue thermogenesis
Sebastien M Labbé1, Alexandre Caron1, Damien Lanfray1
1Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Department of Medicine, Université Laval Québec, QC, Canada.
Frontiers in Systems Neuroscience
|November 19, 2015
Summary
The central nervous system regulates brown adipose tissue (BAT) thermogenesis via the sympathetic nervous system (SNS). This review details hypothalamic control, energy balance, and key neuronal systems involved in BAT activation.
Area of Science:
- Neuroscience
- Metabolic Regulation
- Physiology
Background:
- Brown adipose tissue (BAT) thermogenesis is centrally controlled by the nervous system.
- Sympathetic nervous system (SNS) activation is crucial for BAT activity.
- Neuronal circuits governing BAT thermogenesis involve the hypothalamus, brainstem, and SNS.
Purpose of the Study:
- To review recent advances in the hypothalamic regulation of BAT metabolism.
- To explore the interplay between thermoregulation and energy balance systems.
- To highlight key neuronal systems and homeostatic factors influencing BAT thermogenesis.
Main Methods:
- Literature review synthesizing current research on BAT thermogenesis.
- Analysis of neuronal circuits controlling BAT activation.
- Examination of molecular and systems-level interactions.
Main Results:
- Hypothalamic pathways integrate various stimuli to control BAT thermogenesis via the SNS.
- Melanocortin and endocannabinoid systems play significant roles.
- Steroidogenic factor 1 (SF1) neurons are emerging as key players in BAT thermogenesis.
Conclusions:
- The hypothalamus is central to regulating BAT metabolism and energy balance.
- Understanding these neuronal circuits offers insights into metabolic diseases.
- Further research into homeostatic factors modulating these systems is warranted.
Keywords:
brown adipose tissueendocannabinoidhypothalamusmelanocortinnon-shivering thermogenesissteroidogenic factor 1More Related Videos
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