Related Experiment Video

Updated: Mar 30, 2026

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
09:20

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

Published on: May 4, 2021

4.4K

Adipokines, diabetes and atherosclerosis: an inflammatory association

Leandro C Freitas Lima1, Valdir de Andrade Braga2, Maria do Socorro de França Silva2

  • 1Biological Sciences Institute, Federal University of Minas Gerais Belo Horizonte, Brazil.

Frontiers in Physiology
|November 19, 2015
PubMed

Insights

Diabetes increases cardiovascular disease risk, linked to inflammation. This review explores how adipokines from adipose tissue impact diabetes and atherosclerosis, suggesting potential therapeutic targets.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Metabolic Diseases

Background:

  • Cardiovascular diseases are the leading cause of death in diabetic patients.
  • Diabetes mellitus exacerbates the risk of cardiovascular events.
  • Inflammation is a key factor in the development of diabetes and atherosclerosis.

Purpose of the Study:

  • To review the role of adipokines in the pathophysiology of diabetes.
  • To examine the influence of adipokines on atherosclerosis development.
  • To identify therapeutic strategies targeting adipokine signaling pathways.

Main Methods:

  • Literature review of scientific articles.
  • Analysis of adipokine functions in metabolic and cardiovascular diseases.
  • Exploration of translational models and human studies.

Main Results:

  • Adipokines play a dual role, with both pro- and anti-inflammatory effects.
  • Specific adipokines are implicated in the progression of diabetes and atherosclerosis.
  • Dysregulation of adipokine signaling contributes to disease pathogenesis.

Conclusions:

  • Adipokines are critical mediators in diabetes and atherosclerosis.
  • Targeting adipokine pathways offers promising therapeutic avenues.
  • Further research in humans and translational models is needed to validate these strategies.

Keywords:
IL-6MCP-1TNFαadipokinesadiponectinatherosclerosisdiabetesleptin

More Related Videos

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

1.1K
Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance09:48

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance

Published on: February 17, 2023

3.7K

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.6K
Inflammation01:38

Inflammation

Overview
64.3K
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
604
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
2.0K
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
1.9K
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
582