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Modeling Chronic Traumatic Encephalopathy: The Way Forward for Future Discovery.
Ryan C Turner1, Brandon P Lucke-Wold1, Aric F Logsdon2
1Department of Neurosurgery, West Virginia University School of Medicine , Morgantown, WV , USA ; Center for Neuroscience, West Virginia University School of Medicine , Morgantown, WV , USA.
Frontiers in Neurology
|November 19, 2015
Summary
Understanding chronic traumatic encephalopathy (CTE) requires further research into preclinical models. Current rodent models show promise in mimicking some CTE aspects, but more studies are needed to fully understand disease development.
Area of Science:
- Neuroscience
- Neuropathology
- Traumatic Brain Injury Research
Background:
- Chronic traumatic encephalopathy (CTE) diagnosis receives significant media attention, yet its underlying pathophysiology is poorly understood.
- Research into CTE pathophysiology using preclinical models is a recent development.
- Existing rodent models can replicate certain aspects of CTE through various assays.
Purpose of the Study:
- To explore unanswered questions regarding CTE development using preclinical models.
- To investigate the influence of impact severity, timing, age, and number of impacts.
- To examine the role of impact characteristics, environment, lifestyle, and genetics.
Main Methods:
- Review and analysis of existing studies employing single- and repetitive-injury paradigms in rodent models.
- Utilizing neuropathological, biochemical, and behavioral assays to assess CTE-like features.
- Focus on characterizing the development of tau-based pathology in acute and chronic studies.
Main Results:
- Some preclinical models have successfully replicated certain deficits similar to CTE symptoms.
- Current models provide a foundation but require further refinement for comprehensive CTE recapitulation.
- Significant gaps remain in understanding the full spectrum of neuropathological and neurobehavioral changes.
Conclusions:
- Further research is essential to fully elucidate the development of CTE-like neuropathological and neurobehavioral features in rodents.
- Acute and chronic studies are necessary to characterize tau-based pathology progression.
- Continued investigation using preclinical models is crucial for advancing CTE understanding.
