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Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
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Bile acid signaling and biliary functions.

Hannah Jones1, Gianfranco Alpini2, Heather Francis2

  • 1Baylor Scott & White Digestive Disease Research Center, Temple, TX 76504, USA.

Acta Pharmaceutica Sinica. B
|November 19, 2015
PubMed
Summary

Bile acids impact cholangiocyte function through signaling pathways involving TGR5 and FXR. Understanding these interactions offers potential therapeutic targets for cholangiopathies.

Keywords:
ABCB4, ATP-binding cassette, sub-family BAE2, anion exchanger 2AKT, protein kinases BASBT, apical sodium bile acid transporterBA, bile acidBASIC, bile acid sensitive ion channelBile acidsCOX-2, cyclooxygenase-2CYP27, sterol-27-hydroxylaseCYP7A1, cholesterol 7α-hydroxylaseCa2+, intracellular calciumCholangiocytesCl−/HCO3−, chloride bicarbonate exchangerEGFR, epidermal growth factor receptorERK, extracellular regulated protein kinasesFGF, fibroblast growth factorFXR, farnesoid X receptorHGF, hepatocyte growth factorIL-6, interleukin-6MAPK, mitogen-activated protein kinaseOST, organic solute transporterPBC, primary biliary cirrhosisPC-1, polycystin-1PM, plasma membranePSC, primary sclerosing cholangitisReceptorsS1P, sphingosine-1-phosphateS1PR2, sphingosine 1-phosphate receptor 2SR, secretin receptorSignalingTCA, taurocholic acidTGR5, transmembrane G protein coupled receptorUDCA, ursodeoxycholic acid

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