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Drugs for Treatment of Constipation-Predominant IBS01:21

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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
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Drugs for Treatment of Diarrhea-Predominant IBS01:17

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Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
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Drugs Affecting GI Tract Motility: Other Laxatives01:20

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Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
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Current developments in pharmacological therapeutics for chronic constipation.

Chunhuan Jiang1, Qinglong Xu1, Xiaoan Wen1

  • 1State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing 210009, China.

Acta Pharmaceutica Sinica. B
|November 19, 2015
PubMed
Summary
This summary is machine-generated.

Chronic constipation significantly impacts quality of life, with new drugs offering hope. Promising investigational therapies include 5-HT4 receptor modulators, guanylate cyclase C agonists, and ileal bile acid transporter inhibitors.

Keywords:
5-HT, serotonin5-HT4 receptorCC, chronic constipationCDCA, chenodeoxycholic acidCFTR, cystic fibrosis transmembrane conductance regulatorCIC, chronic idiopathic constipationCaCC, calcium-activated chloride channelChronic constipationClC-2, chloride channel protein 2ENaC, epithelial sodium channelGC-C, guanylate cyclase CGI, gastrointestinalIBAT, the ileal bile acid transporter (also known as apical sodium-dependent bile acid transporter)IBS-C, irritable bowel syndrome with constipationIPAN, intrinsic primary afferent neuronsLGP, lubricating gut pillNHE3, sodium-hydrogen exchanger 3OIC, opioid-induced constipationPKGII, protein kinase IIProkinetic agentProsecretory agentSBMs, spontaneous bowel movementsTGR5, the G-protein-coupled bile acid receptorhERG, human ether-à-go-go–related gene

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Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Chronic constipation is a prevalent gastrointestinal disorder.
  • Current treatments like laxatives have limitations.
  • Approved drugs include lubiprostone, linaclotide, and prucalopride.

Purpose of the Study:

  • To provide a comprehensive review of pharmacological therapeutics for chronic constipation.
  • To highlight emerging drug development trends in this field.

Main Methods:

  • Literature review of pharmacological treatments for chronic constipation.
  • Analysis of recently approved and investigational drugs.

Main Results:

  • Several new drugs have been approved for chronic constipation.
  • Investigational drugs such as velusetrag, naronapride, plecanatide, and elobixibat show promise.
  • A significant unmet medical need persists for patients with poor response to current therapies.

Conclusions:

  • The field of chronic constipation treatment is evolving with novel therapeutic agents.
  • Further research and development are crucial to address remaining unmet medical needs.