Related Experiment Video
Updated: Mar 30, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
GRANULOMATOSIS WITH POLYANGIITIS (GPA) PRESENTING WITH FROSTED BRANCH ANGIITIS
Rasanamar K Sandhu1, Tony Adams, Cailin Sibley
1*Casey Eye Institute, Oregon Health and Science University, Portland, Oregon; †Department of Medicine, Oregon Health and Science University, Portland, Oregon; ‡Rheumatology Division, Oregon Health and Science University, Portland, Oregon; and §Veterans Administration Portland Health Care System, Portland, Oregon.
Purpose:
To report a case of frosted branch angiitis in a patient with granulomatosis with polyangiitis.
Methods:
Clinical case report. Imaging was obtained with pseudo-color scanning laser ophthalmoscope photographs, fluorescein angiography, spectral domain optical coherence tomography, and B-scan ultrasound.
Results:
A 24-year-old woman with a clinical history of granulomatosis with polyangiitis who presented with acute vision loss was found to have frosted branch angiitis with concurrent posterior scleritis and orbital inflammation. These findings improved rapidly after initiation of high-dose intravenous solumedrol.
Conclusion:
This is a unique case of frosted branch angiitis associated with granulomatosis with polyangiitis. The authors are not aware of a previous report of this association. Although rare, retinal vasculitis should be recognized as a potential complication of granulomatosis with polyangiitis and can respond rapidly to prompt initiation of therapy.
More Related Videos
10:46Retinal Cryo-sections, Whole-Mounts, and Hypotonic Isolated Vasculature Preparations for Immunohistochemical Visualization of Microvascular Pericytes
Published on: October 7, 2018
05:14Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
Published on: August 11, 2023
Related Concept Videos
Peripheral Artery Disease I: Introduction
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Endocarditis II: Clinical Features of Infective Endocarditis
Nephrotic Syndrome I : Introduction