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Updated: Mar 30, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Prolonged and Severe Gestational Thyrotoxicosis Due to Enhanced hCG Sensitivity of a Mutant Thyrotropin Receptor
Anne Laure Coulon1, Frédérique Savagner1, Claire Briet1
1Endocrinologie (A.L.C., O.C.), Centre Hospitalier Universitaire de Grenoble, 38700, La Tronche, France; Département de Biochimie et Génétique (F.S.), Centre Hospitalier Universitaire d'Angers, 49000 Angers, France; Centre National de la Recherche Scientifique 6214/Institut National de la Sante et de la Recherche Medicale 1083 (C.B., M.M., P.R.), Université d'Angers, 49000 Angers, France; Endocrinologie (C.B., M.M., P.R.), Centre de Référence des Maladies Rares de la Réceptivité Hormonale, Centre Hospitalier Universitaire d'Angers, 49000 Angers, France; and Groupe Hospitalier Mutualiste des Eaux-Claires (M.V.), 38028 Grenoble, France.
Context:
Gestational thyrotoxicosis, whether associated with hyperemesis gravidarum or not, is thought to be due to excessive human chorionic gonadotropin (hCG) secretion.
Case Description:
We report here the second case of gestational thyrotoxicosis associated with hyperemesis gravidarum due to a mutation of the TSH receptor, providing thyroid hypersensitivity to hCG.
Conclusion:
Severe and lasting gestational thyrotoxicosis with normal hCG concentration should lead to sequencing of the TSH receptor gene.
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