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Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
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Reducing neurodevelopmental disorders and disability through research and interventions.

Michael J Boivin1,2, Angelina M Kakooza3, Benjamin C Warf4

  • 1Department of Psychiatry, College of Osteopathic Medicine, 965 Fee Road, East Fee Hall Room 225, Michigan State University, East Lansing, Michigan 48824, USA.

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Advances in understanding genetic and epigenetic causes of neurodevelopmental disorders are crucial for developing effective interventions. Strategic, cross-disciplinary research in low- and middle-income countries can significantly improve child health and development globally.

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Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Biology
  • Public Health

Background:

  • Neurodevelopment involves complex interactions between genetic, brain, cognitive, emotional, and behavioral processes throughout life.
  • Disruptions to neurodevelopment, influenced by genetic and environmental risks, can result in neurodevelopmental disorders and disabilities.
  • Research in low- and middle-income countries (LMICs) is vital for addressing these disorders globally.

Purpose of the Study:

  • To highlight advances in understanding and ameliorating neurodevelopmental disorders, particularly in LMICs.
  • To identify strategic research opportunities for prevention, treatment, and rehabilitation.
  • To emphasize the importance of cross-disciplinary integration in neurodevelopmental research.

Main Methods:

  • Reviewing and providing examples of research innovations in LMICs for neurodevelopmental disorders.
  • Integrating genotypic mapping with environmental and cultural factors.
  • Examining epigenetic influences on neurodevelopmental risk and resilience.

Main Results:

  • Innovations in identification, surveillance, and treatment of neurodevelopmental disorders in LMICs.
  • Development of preventative and rehabilitative interventions through integrated genotypic mapping.
  • Enhanced understanding of how epigenetic factors shape neurodevelopmental outcomes.

Conclusions:

  • Cross-disciplinary research at the intersection of environment, brain/behavior, and genetics/epigenetics is key.
  • Integrative scientific approaches are creating novel technologies and interventions for neurodevelopmental disorders.
  • These efforts support the global mandate for child health and development as a human right.