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Effect of Circadian Rhythm Disruption and Alcohol on the Oxidative Stress Level in Rat Brain
Miroslava Georgieva Varadinova1, Maria Lozanova Valcheva-Traykova, Nadka Ivanova Boyadjieva
1Departments of 1Pharmacology and Toxicology; and 2Medical Physics and Biophysics, Medical Faculty, Medical University, Sofia, Bulgaria.
Abstract:
Alcohol abuse is often associated with disrupted circadian rhythms and sleep, and the link seems to be bidirectional. In addition, it has been shown that exposure to constant illumination may increase lipid peroxidation in tissues. In this study, we investigated the effects of circadian rhythm disruption (CRD) and chronic alcohol intake (A) alone and in combination (CRD+A), on the oxidative stress in total rat brain homogenate. Our results demonstrated that lipid peroxidation was increased in the brain samples of all experimental animals compared with the control ones. The oxidative stress levels increased in the order: C
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