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Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)

Mohammed I Y Elmallah1,2, Olivier Micheau3,4

  • 1Department of Chemistry, Faculty of Science, Helwan University, Ain Helwan, Cairo 11790, Egypt. mohamed_almallah@science.helwan.edu.eg.

Marine Drugs
|November 19, 2015
PubMed

Insights

Marine compounds can restore cancer cell sensitivity to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced death. This review explores how marine bioactive compounds overcome TRAIL resistance, aiding tumor immune surveillance.

Area of Science:

  • Marine biology
  • Pharmacology
  • Oncology

Background:

  • Marine biomass is a rich source of anticancer compounds.
  • Natural marine products can restore tumor cell sensitivity to TNF-related apoptosis-inducing ligand (TRAIL)-induced cell death.
  • TRAIL plays a role in tumor immune surveillance and exhibits selectivity for cancer cells, making it a target in oncology.

Purpose of the Study:

  • To discuss the regulatory mechanisms of TRAIL signaling.
  • To present marine bioactive compounds that overcome TRAIL resistance in tumor cells.

Main Methods:

  • Literature review of studies on marine bioactive compounds and TRAIL signaling.
  • Analysis of mechanisms regulating TRAIL-induced apoptosis.
  • Identification of marine compounds that enhance TRAIL sensitivity.

Main Results:

  • TRAIL signaling is tightly regulated through various pathways.
  • Marine bioactive compounds have demonstrated the ability to restore sensitivity to TRAIL-induced apoptosis in resistant cancer cells.
  • Specific marine compounds and their mechanisms of action in overcoming TRAIL resistance are identified.

Conclusions:

  • Marine bioactive compounds represent a promising strategy to overcome TRAIL resistance in cancer therapy.
  • Further research into these compounds could lead to novel anticancer treatments targeting TRAIL pathways.
  • Leveraging marine natural products offers a potential avenue to enhance the efficacy of TRAIL-based cancer therapies.
Keywords:
ApoptosisTNFTRAILalkaloidscancercarotenoidsmacrolactonesmarine drugsresistancesesquiterpenes

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