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Epilepsy and Seizures: Overview

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...

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Updated: Mar 30, 2026

Chronic Transcranial Electrical Stimulation and Intracortical Recording in Rats

Chronic Transcranial Electrical Stimulation and Intracortical Recording in Rats

Published on: May 11, 2018

Responsive neurostimulation in epilepsy.

Sofie Carrette¹, Paul Boon¹, Mathieu Sprengers¹

¹a Laboratory for Clinical and Experimental Neurophysiology, Neurobiology and Neuropsychology (LCEN3), Ghent University, Department of Neurology , Ghent University Hospital, Institute for Neuroscience , Ghent , Belgium.

Expert Review of Neurotherapeutics

|November 19, 2015

Summary

This summary is machine-generated.

Responsive neurostimulation offers a promising approach to epilepsy treatment by delivering electrical stimulation to prevent seizures. While challenging to design, this targeted therapy shows potential for improved efficacy and safety in managing epilepsy.

Keywords:

closed-loop deep brain stimulation (DBS)drug delivery system epilepsy neurostimulation optogenetics responsive responsive neurostimulation system (RNS)vagus nerve stimulation (VNS)

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A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

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A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

Area of Science:

Neurology
Biomedical Engineering
Epilepsy Research

Background:

Neurostimulation is an established epilepsy therapy with favorable efficacy and safety.
Responsive neurostimulation aims to abort seizures by detecting and intervening in early seizure activity.

Purpose of the Study:

To explore the potential of responsive neurostimulation as an epilepsy treatment.
To highlight the technological challenges and benefits of responsive neurostimulation.

Main Methods:

Review of current responsive neurostimulation strategies in epilepsy.
Analysis of the requirements for sensing and stimulation algorithms in responsive devices.

Main Results:

Responsive neurostimulation technology is more complex than open-loop systems.
Successful responsive stimulation relies on precise algorithms and rapid sensor-stimulator coupling.

Conclusions:

Responsive neurostimulation shows promise for epilepsy management by delivering targeted intervention.
Further research is needed to fully understand the benefits of this advanced neurostimulation technique.