Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Suctioning the Nasopharyngeal Airway01:29

Suctioning the Nasopharyngeal Airway

5.2K
Nasopharyngeal suctioning is a procedure to remove secretions from the upper part of the respiratory tract that the patient cannot clear independently. It helps maintain airway patency and prevents complications such as aspiration pneumonia.
Equipment Required
5.2K
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics01:23

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

1.6K
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla.  Benzonatate operates peripherally within the respiratory tract by...
1.6K
Suctioning the Oropharyngeal Airway01:25

Suctioning the Oropharyngeal Airway

1.4K
In preparing for oropharyngeal airway suctioning, a nurse must gather all necessary equipment, including a suction unit with tubing, a prepackaged suction kit, sterile gloves, water or saline for irrigation, a water-soluble lubricant, and additional personal protective equipment (such as a gown, mask, and goggles) to control infections.
After assembling the equipment, the nurse should practice hand hygiene and don appropriate PPE according to infection control guidelines to avoid the...
1.4K
Drugs Used in Upper Respiratory Disorders: Overview01:16

Drugs Used in Upper Respiratory Disorders: Overview

996
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
996
Salivary Glands and Saliva01:23

Salivary Glands and Saliva

3.2K
The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...
3.2K
Gross Anatomy of the Lungs01:17

Gross Anatomy of the Lungs

6.2K
The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oesophageal functional phenotypes in refractory gastro-oesophageal reflux disease-related chronic cough.

ERJ open research·2026
Same author

Risk Factors for COVID-19 mRNA Vaccine-Associated Exacerbations in Patients With Obstructive Airway Diseases: REsearch for Asthma and COPD ExacerbaTION Caused by COVID-19 mRNA Vaccination (REACTION Study).

Allergy, asthma & immunology research·2026
Same author

Characteristic computed tomography features of mild-to-moderate Legionella pneumonia: evaluation of a known pattern and identification of a novel indicator.

BMC pulmonary medicine·2026
Same author

Outcomes following the discontinuation of biologic therapy in patients with severe asthma.

Allergology international : official journal of the Japanese Society of Allergology·2026
Same author

[COMPREHENSIVE APPROACH TO CHRONIC ALLERGIC/INFLAMMATORY AIRWAY DISEASES].

Arerugi = [Allergy]·2025
Same author

Prevalence of Laryngeal Abnormal Sensation in a Hospital Worker Population and its Association with Cough Hypersensitivity.

Lung·2025

Related Experiment Video

Updated: Mar 30, 2026

Precision Induction and Distinction of Coughing and Sneezing Reflexes in Mice
09:30

Precision Induction and Distinction of Coughing and Sneezing Reflexes in Mice

Published on: October 3, 2025

1.6K

Mechanical Stimulation by Postnasal Drip Evokes Cough.

Toshiyuki Iwata1, Isao Ito1, Akio Niimi1,2

  • 1Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Plos One
|November 19, 2015
PubMed
Summary

Mechanical stimuli from postnasal drip cause chronic cough in humans and animal models. Blocking this drip completely inhibited cough, suggesting new drug targets for cough relief.

More Related Videos

Methods for Detecting Cough and Airway Inflammation in Mice
04:33

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

1.5K
Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid
05:43

Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid

Published on: January 10, 2025

1.4K

Related Experiment Videos

Last Updated: Mar 30, 2026

Precision Induction and Distinction of Coughing and Sneezing Reflexes in Mice
09:30

Precision Induction and Distinction of Coughing and Sneezing Reflexes in Mice

Published on: October 3, 2025

1.6K
Methods for Detecting Cough and Airway Inflammation in Mice
04:33

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

1.5K
Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid
05:43

Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid

Published on: January 10, 2025

1.4K

Area of Science:

  • Physiology
  • Pharmacology
  • Otolaryngology

Background:

  • Cough is a common condition with significant economic impact.
  • Current cough research heavily relies on animal models, limiting understanding of human cough.
  • Postnasal drip is a suspected, yet debated, cause of chronic cough.

Purpose of the Study:

  • To investigate the role of mechanical stimuli from postnasal drip in causing chronic cough.
  • To differentiate cough from other expiratory reflexes based on airflow patterns.
  • To identify potential therapeutic targets for cough by understanding its root cause.

Main Methods:

  • Analysis of human expiratory airflow patterns to distinguish cough from sneezes and expiration reflexes.
  • Utilizing transgenic mice with ciliary dyskinesia to model cough and postnasal drip.
  • Implementing nasal airway blockade in mice to assess the effect on cough.
  • Reproducing cough in wild-type mice by introducing artificial postnasal drip.

Main Results:

  • Cough and sneeze exhibit distinct expiratory airflow patterns (one-peak vs. two-peak).
  • Transgenic mice with postnasal drip exhibited significant coughing, which was fully suppressed by nasal blockade.
  • Artificial postnasal drip successfully induced cough in wild-type mice.
  • Mechanical stimulation by postnasal drip was confirmed as a cause of cough.

Conclusions:

  • Mechanical stimulation from postnasal drip is a direct cause of chronic cough.
  • The study provides a mechanistic link between postnasal drip and cough.
  • Findings support the development of novel antitussive drugs targeting the mechanical cause of cough.