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Hyperglycemia is a risk factor for high-grade envenomations after European viper bites (Vipera spp.) in children

I Claudet1, E Grouteau1, L Cordier2

  • 1a Pediatric Emergency Department , Children Hospital , Toulouse , France ;

Clinical Toxicology (Philadelphia, Pa.)
|November 20, 2015
PubMed

Insights

Initial hyperglycemia is a significant risk factor for severe viper bites in children. This finding helps predict envenomation severity and guide treatment decisions in pediatric cases.

Area of Science:

  • Pediatric Emergency Medicine
  • Toxicology
  • Herpetology

Background:

  • Hyperglycemia is noted in severe scorpion stings.
  • The study investigated hyperglycemia in pediatric viper bites.

Purpose of the Study:

  • To characterize clinical, biological, and therapeutic aspects of European viper bites in 83 children.
  • To confirm hyperglycemia as a risk factor for high-grade envenomation.

Main Methods:

  • Retrospective study (2001-2014) at a pediatric tertiary hospital.
  • Data collected: demographics, accident details, snake ID, bite location, envenomation severity, lab results, treatment, and outcomes.
  • Analysis of factors associated with high-grade envenomation.

Main Results:

  • 83 children (mean age 7.4 years) were included; 17% had high-grade envenomation.
  • Risk factors for high-grade envenomation included upper extremity bites, afternoon bites, severe pain, and high initial plasma glucose.
  • Children with high-grade envenomation received specific immunotherapy (Viperfav™).

Conclusions:

  • A link between initial hyperglycemia and the risk of severe viper envenomation in children is confirmed.
  • Hyperglycemia is identified as a predictive factor for envenomation severity.
  • Findings support incorporating glucose monitoring in pediatric viper bite management.
Abstract

Keywords:
Viper biteenvenomationhigh gradehyperglycemiapediatric

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