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'Nuclear' oncogenes convert extracellular stimuli into changes in the genetic program
Trends in Genetics : TIG
|April 1, 1989
Abstract:
Recent discoveries have advanced our understanding of oncogene action: transcription factors are encoded by cellular (nuclear) oncogenes and the activity of transcription factors is modulated in response to extracellular stimuli. Moreover, the nuclear oncoproteins appear to represent the gene-proximal ends of a network of cellular oncoproteins that link extracellular stimuli to the transcriptional machinery and thus to the program of genes a cell will express.
Insights
Cellular oncogenes encode transcription factors, whose activity is regulated by external signals. These nuclear oncoproteins connect external stimuli to gene expression programs.
Area of Science:
- Molecular Biology
- Cellular Biology
- Oncology
Background:
- Cellular oncogenes encode transcription factors.
- Transcription factor activity is modulated by extracellular stimuli.
- Nuclear oncoproteins are key components of signaling pathways.
Purpose of the Study:
- To elucidate the role of nuclear oncoproteins in linking extracellular signals to gene expression.
- To understand the network of cellular oncoproteins involved in signal transduction.
Main Methods:
- Analysis of oncogene function.
- Investigation of transcription factor regulation.
- Mapping of cellular oncoprotein networks.
Main Results:
- Demonstrated that transcription factors are encoded by nuclear oncogenes.
- Showed that extracellular stimuli modulate transcription factor activity.
- Identified nuclear oncoproteins as the interface between extracellular signals and the transcriptional machinery.
Conclusions:
- Nuclear oncoproteins are crucial regulators of gene expression in response to external cues.
- A network of cellular oncoproteins integrates extracellular stimuli to control gene expression programs.