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Related Experiment Videos

'Nuclear' oncogenes convert extracellular stimuli into changes in the genetic program.

P Herrlich, H Ponta

    Trends in Genetics : TIG
    |April 1, 1989
    PubMed
    Summary

    Cellular oncogenes encode transcription factors, whose activity is regulated by external signals. These nuclear oncoproteins connect external stimuli to gene expression programs.

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    Area of Science:

    • Molecular Biology
    • Cellular Biology
    • Oncology

    Background:

    • Cellular oncogenes encode transcription factors.
    • Transcription factor activity is modulated by extracellular stimuli.
    • Nuclear oncoproteins are key components of signaling pathways.

    Purpose of the Study:

    • To elucidate the role of nuclear oncoproteins in linking extracellular signals to gene expression.
    • To understand the network of cellular oncoproteins involved in signal transduction.

    Main Methods:

    • Analysis of oncogene function.
    • Investigation of transcription factor regulation.
    • Mapping of cellular oncoprotein networks.

    Main Results:

    • Demonstrated that transcription factors are encoded by nuclear oncogenes.
    • Showed that extracellular stimuli modulate transcription factor activity.
    • Identified nuclear oncoproteins as the interface between extracellular signals and the transcriptional machinery.

    Conclusions:

    • Nuclear oncoproteins are crucial regulators of gene expression in response to external cues.
    • A network of cellular oncoproteins integrates extracellular stimuli to control gene expression programs.

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