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Towards the emerging crosstalk: ERBB family and steroid hormones

Gabriele D'Uva1, Mattia Lauriola2

  • 1Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel.

Seminars in Cell & Developmental Biology
|November 20, 2015
PubMed

Insights

Steroid hormones and ERBB receptor tyrosine kinases (RTKs) crosstalk impacts cellular processes. Understanding these interactions offers new insights into diseases like cancer and potential therapeutic strategies.

Area of Science:

  • Molecular Biology
  • Cellular Signaling
  • Endocrinology

Background:

  • Receptor tyrosine kinases (RTKs) of the ERBB family and steroid hormone nuclear receptors (NRs) are key regulators of cellular functions.
  • Dysregulation of ERBB and steroid hormone receptors is implicated in various diseases, notably cancer.
  • An emerging crosstalk between these two critical receptor systems is increasingly recognized.

Purpose of the Study:

  • To review and elucidate the crosstalk between ERBB receptor tyrosine kinases and steroid hormone receptors.
  • To explore the mechanisms underlying this crosstalk, including genomic and non-genomic interactions.
  • To highlight how steroid hormones modulate ERBB signaling pathways and affect cellular outcomes.

Main Methods:

  • Literature review of recent studies on ERBB-steroid hormone receptor interactions.
  • Analysis of genomic and non-genomic mechanisms mediating crosstalk.
  • Discussion of the impact of this crosstalk on cellular signaling and disease.

Main Results:

  • Steroid hormones can fine-tune ERBB receptor feedback loops, influencing cellular output.
  • The crosstalk involves complex genomic and non-genomic interactions.
  • This interplay is crucial for understanding biological complexity in health and disease.

Conclusions:

  • The interactions between steroid hormones and RTKs warrant further investigation.
  • A systems biology approach and advanced technologies are needed to study RTK-SH crosstalk.
  • Understanding this crosstalk may reveal novel therapeutic targets for diseases, including cancer.
Keywords:
Cancer therapyChronotherapyEGFRFeedback regulationGlucocorticoid receptorNegative feedbackPositive feedbackReceptor tyrosine kinaseRegulatory crosstalkSteroid hormonesTetheringTransactivationTransrepression

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