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Updated: Mar 30, 2026

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing
Published on: January 12, 2021
High-throughput sequencing insights into T-cell receptor repertoire diversity in aging
Jörg J Goronzy1,2, Qian Qi3,4, Richard A Olshen5
1Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA. jgoronzy@stanford.edu.
Abstract:
Decline in T-cell generation leading to T-cell receptor repertoire contraction is a cornerstone of immune system aging, and consequent disorders. High-throughput sequencing enables in-depth immune repertoire characterization, but blood samples are too small to capture its total diversity. New computational models could enable accurate estimation of this diversity.
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