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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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Related Experiment Video

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Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
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[Neuroendocrine prostate cancer].

A Kretschmer1, C Wittekind2, C G Stief3

  • 1Urologische Klinik und Poliklinik, Klinikum der Universität München, Ludwig-Maximilians Universität München, Campus Großhadern, Marchioninistraße 15, 81377, München, Deutschland. Alexander.kretschmer@med.uni-muenchen.de.

Der Urologe. Ausg. A
|November 20, 2015
PubMed
Summary

Neuroendocrine carcinoma of the prostate (NEPC) is a rare, aggressive cancer. Current treatments are ineffective, necessitating novel therapeutic strategies for this challenging prostate cancer variant.

Keywords:
AdenocarcinomaHistomorphologySmall cell prostate cancerTransdifferentiation, neuroendocrineTumors, neuroendocrine

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Area of Science:

  • Oncology
  • Uropathology

Context:

  • Neuroendocrine carcinoma of the prostate (NEPC) is a rare, aggressive prostate cancer variant.
  • NEPC exhibits distinct tumor biology, rendering standard prostate cancer therapies ineffective.
  • The incidence of NEPC is increasing, highlighting an unmet clinical need.

Purpose:

  • To review the histopathologic features and classifications of NEPC.
  • To outline current and emerging treatment strategies for NEPC.
  • To differentiate NEPC from neuroendocrine transdifferentiated adenocarcinoma of the prostate.

Summary:

  • Histomorphologic classifications aid in distinguishing NEPC subtypes, influencing prognosis and treatment.
  • Platinum-based chemotherapy remains a standard treatment for NEPC.
  • Antiangiogenic drugs are under investigation as potential NEPC therapies.

Impact:

  • Understanding NEPC subtypes is crucial for tailoring treatment approaches.
  • Effective NEPC treatment requires strategies distinct from those for prostate adenocarcinoma.
  • Further research is needed due to limited data on NEPC treatment efficacy.