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Multichannel quartz crystal microbalance array: Fabrication, evaluation, application in biomarker detection.

Wenyan Tao1, Peng Lin2, Yanqing Ai3

  • 1Shenzhen Key Laboratory of Special Functional Materials & Shenzhen Engineering Laboratory for Advance Technology of Ceramics, College of Materials Science and Engineering, Shenzhen University, Shenzhen, China; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, China.

Analytical Biochemistry
|November 20, 2015
PubMed
Summary

A novel multichannel quartz crystal microbalance (MQCM) array was developed for detecting acetone and nitric oxide (NO) biomarkers. This sensor utilizes nanocomposite materials, offering sensitive and selective gas detection capabilities.

Keywords:
AcetoneMultichannel quartz crystal microbalance arrayMultiwalled carbon nanotubeNitric oxide

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Area of Science:

  • Materials Science
  • Analytical Chemistry
  • Sensor Technology

Background:

  • Biomarker detection is crucial for diagnostics.
  • Quartz Crystal Microbalance (QCM) sensors offer high sensitivity.
  • Developing selective and sensitive sensors for gases like acetone and nitric oxide (NO) remains a challenge.

Purpose of the Study:

  • To fabricate a multichannel quartz crystal microbalance array (MQCM) for simultaneous detection of acetone and nitric oxide (NO).
  • To optimize the MQCM device fabrication, specifically gold electrode thickness.
  • To synthesize and evaluate nanocomposite materials for enhanced sensing performance.

Main Methods:

  • Fabrication of a 10 MHz MQCM using photolithography, sputtering, and lift-off techniques.
  • Optimization of gold electrode thickness (101 nm) for improved MQCM performance.
  • Synthesis of titanium dioxide-multiwalled carbon nanotubes and cobalt (II)phthalocyanine-silica nanocomposites as sensing layers.

Main Results:

  • The fabricated MQCM exhibited good resonance performance with simulated electric parameters within theoretical ranges.
  • Optimized gold layer thickness at 101 nm enhanced MQCM performance.
  • The sensor demonstrated a linear detection range of 4.33–129.75 ppmv for acetone and 5.75–103.45 ppbv for NO.

Conclusions:

  • The developed MQCM array with nanocomposite sensing materials is effective for detecting acetone and NO.
  • The sensor design and material selection provide a promising platform for sensitive and selective gas biomarker monitoring.
  • Further research can explore broader applications in environmental monitoring and medical diagnostics.