Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

High Mutation Rates in Non-human Primates Edited by Cytosine Base Editors.

Genomics, proteomics & bioinformatics·2026

Same author

Real-World Efficacy and Safety of TACE Combined with Lenvatinib and PD-1 Inhibitor in Conversion Therapy for Unresectable Hepatocellular Carcinoma (GUIDANCE007): A Multicenter Retrospective Study.

Liver cancer·2026

Same author

Image feature embedding with a deep learning framework improves genome-wide association studies on dog endophenotypes.

Science advances·2026

Same author

Social communicative characteristics of adolescent police dogs: Acquired experience plays a crucial role.

Animal cognition·2026

Same author

Neoadjuvant transarterial chemoembolization with tyrosine kinase and immune checkpoint inhibitors improves survival from resectable hepatocellular carcinoma in a multicenter, retrospective study (GUIDANCE002).

Communications medicine·2026

Same author

Clinical and Prognostic Features of Perioperative Stroke: A Multicenter Retrospective Cohort Study.

Cerebrovascular diseases extra·2026

Search research articles

Related Experiment Video

Updated: Mar 30, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

[Recent advances in transmissible tumors].

Ting-ting Yin¹, Lu Wang², Guo-dong Wang³

¹1. Molecular Evolution and Genome Diversity Lab, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China; 2. Kunming College of Life Science, University of Chinese Academy of Sciences,Kunming 650204, China;

Yi Chuan = Hereditas

|November 20, 2015

Summary

Transmissible tumors, like canine transmissible venereal tumor (CTVT), can spread between individuals. Recent genomic studies reveal insights into their evolution and transmission mechanisms.

More Related Videos

Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer

Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer

Published on: March 26, 2014

Identification and Characterization of Metastatic Factors by Gene Transfer into the Novel RIP-Tag; RIP-tva Murine Model

Identification and Characterization of Metastatic Factors by Gene Transfer into the Novel RIP-Tag; RIP-tva Murine Model

Published on: October 16, 2017

Related Experiment Videos

Last Updated: Mar 30, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer

Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer

Published on: March 26, 2014

Identification and Characterization of Metastatic Factors by Gene Transfer into the Novel RIP-Tag; RIP-tva Murine Model

Identification and Characterization of Metastatic Factors by Gene Transfer into the Novel RIP-Tag; RIP-tva Murine Model

Published on: October 16, 2017

Area of Science:

Comparative oncology
Evolutionary biology
Cell biology

Context:

Transmissible tumors are rare but significant neoplastic diseases.
Four types identified: CTVT, DFTD, SSCL, HRCS.
Transmission occurs via living cells, bypassing host immunity.

Purpose:

To review recent advances in transmissible tumor research.
To highlight genomic insights into tumorigenesis and evolution.
To outline future research directions.

Summary:

Discusses canine transmissible venereal tumor (CTVT) and Tasmanian devil facial tumor disease (DFTD), noting their Schwann cell origin and immune evasion strategies.
Explores soft-shell clams leukemia (SSCL) associated with high copy numbers of the Steamer retrotransposon.
Highlights whole-genome sequencing of CTVT and DFTD for understanding tumor evolution.

Impact:

Genomic data facilitates deeper understanding of transmissible cancer mechanisms.
Provides a foundation for future research into cancer transmission and evolution.
Informs comparative oncology and evolutionary studies of disease.