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[A quick and efficient method to generate hemophilia B mouse models by the CRISPR/Cas system]

Qi-han Wang1, Cong Huai1, Rui-lin Sun2

  • 1State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai 200433, China.

Yi Chuan = Hereditas
|November 20, 2015
PubMed
Summary

Researchers efficiently created hemophilia B mouse models using CRISPR/Cas gene editing. These knockout mice exhibit significantly reduced coagulation factor IX activity, confirming their utility for studying this X-linked bleeding disorder.

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