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A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies
Published on: February 23, 2018
Comment on "Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2"
Anne Vassalli1, Sha Li2, Mehdi Tafti1
1Center for Integrative Genomics, University of Lausanne, CH-1015 Lausanne, Switzerland. mehdi.tafti@unil.ch anne.vassalli@unil.ch.
Abstract:
Did hypocretin receptor 2 autoantibodies cause narcolepsy with hypocretin deficiency in Pandemrix-vaccinated children, as suggested by Ahmed et al.? Using newly developed mouse models to report and inactivate hypocretin receptor expression, Vassalli et al. now show that hypocretin neurons (whose loss causes narcolepsy) do not express hypocretin autoreceptors, raising questions to the interpretation of Ahmed et al.'s findings.
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