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Mass Spectrometry: Complex Analysis01:21

Mass Spectrometry: Complex Analysis

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Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
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This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record the characteristic mass spectra. This is achieved via three chief functions:
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Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...
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MALDI-TOF Mass Spectrometry

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Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...
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Mass Analyzers: Overview01:13

Mass Analyzers: Overview

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The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...
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Mass Spectrometry: Overview01:19

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Mass spectrometry is an analytical technique used to determine the molecular mass and molecular formula of a compound. The basic principle of mass spectrometry is to generate ions from the analyte molecule and measure these ion abundances against their molecular mass. One common type of ionization, known as electron ionization or EI, bombards the analyte molecules in the gas phase with high-energy electron beams. The electron beams displace an electron from the molecule and leave behind a...
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Alpha spectrometry applications with mass separated samples.

M P Dion1, Gregory C Eiden1, Orville T Farmer1

  • 1Pacific Northwest National Laboratory Richland, WA 99354, United States.

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
|November 20, 2015
PubMed
Summary
This summary is machine-generated.

A new technique using inductively coupled plasma mass spectrometry (ICP-MS) enables high-resolution alpha spectrometry for Americium-241 (241Am) and Plutonium-238 (238Pu) samples. This method achieves excellent isotopic separation and detector energy resolution.

Keywords:
ActinideAlpha spectrometryAm-241ICP-MS

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Area of Science:

  • Nuclear Chemistry
  • Analytical Chemistry
  • Radiochemistry

Background:

  • Accurate isotopic analysis is crucial for nuclear material characterization.
  • Traditional sample preparation methods can introduce uncertainties or limitations.

Purpose of the Study:

  • To present a novel technique for depositing Americium-241 (241Am) using inductively coupled plasma mass spectrometry (ICP-MS).
  • To investigate the mass-based separation capabilities for radioisotopes.
  • To achieve high-resolution alpha spectrometry measurements.

Main Methods:

  • Deposition of 241Am using a commercial ICP-MS.
  • High-resolution alpha spectrometry with a passivated implanted planar silicon detector.
  • Development of a Plutonium-238 (238Pu) sample from a Plutonium-244 (244Pu) standard.
  • Radiometric counting for isotopic analysis.

Main Results:

  • The novel ICP-MS deposition technique achieved intrinsic energy resolution for 241Am samples.
  • Effective mass-based separation was demonstrated for 238Pu, with no detectable trace of other isotopes.
  • The method allows for precise radiometric counting and isotopic characterization.

Conclusions:

  • The developed ICP-MS based sample preparation method is effective for producing high-quality samples for alpha spectrometry.
  • This technique significantly enhances isotopic separation capabilities, crucial for accurate radioisotope analysis.
  • The method offers a promising approach for radioanalytical applications requiring high precision and resolution.