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[Drug intolerance caused by pseudo-allergic reactions]
1Dermatologischen Klinik und Poliklinik, Ludwig-Maximilians-Universität München, BRD.
Wiener Medizinische Wochenschrift (1946)
|April 15, 1989
Summary
Pseudo-allergic reactions mimic allergic diseases and can be triggered by drug components or additives. Diagnosis requires provocation tests, as standard skin tests and in-vitro assays are unavailable.
Area of Science:
- Immunology
- Pharmacology
- Clinical Medicine
Context:
- Allergic disease symptoms can be mimicked by non-immunological pseudo-allergic reactions.
- Pseudo-allergic drug reactions may involve active components or excipients.
- Anaphylactoid pseudo-allergic reactions are of significant clinical importance.
Purpose:
- To discuss hypothetical pathomechanisms of pseudo-allergic drug reactions.
- To explore potential, yet unidentified, allergic mechanisms.
- To highlight diagnostic challenges and methods for pseudo-allergic drug reactions.
Summary:
- Pseudo-allergic reactions present symptomatically like allergic diseases but involve non-immunological pathways.
- These reactions can be induced by various drug constituents, including active pharmaceutical ingredients and additives.
- Elucidating the precise pathomechanism of anaphylactoid pseudo-allergic reactions remains an ongoing challenge, necessitating further research.
Impact:
- Improved understanding of pseudo-allergic reactions aids in differential diagnosis of adverse drug events.
- Highlights the limitations of current diagnostic tools, emphasizing the need for advanced in-vitro and in-vivo testing methods.
- Informs clinical practice regarding the evaluation and management of patients presenting with allergy-like symptoms potentially caused by pseudo-allergic drug reactions.