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Relationship Between Cerebrospinal Fluid Protein Levels and Electrophysiologic Abnormalities in Guillain-Barré
Daniel B DiCapua1, Amanda A Lakraj, Richard J Nowak
1*Department of Neurology, Yale University School of Medicine, New Haven, CT; †Department of Neurology, Medical College of Wisconsin, Milwaukee, WI; and ‡Department of Neurology, Hospital for Special Surgery, New York, NY.
Objectives:
The cerebrospinal fluid (CSF) protein level is known to be elevated in patients with Guillain-Barré syndrome (GBS). This report correlates the degree of CSF protein elevation with the number of electrophysiologic abnormalities on nerve conduction study (NCS).
Methods:
We reviewed 38 patients admitted to our institution with a diagnosis of GBS and had both a measured CSF protein level and a NCS within 24 hours of each other.
Results:
CSF protein level correlates with the number of NCS demyelination criteria, as described by Cornblath, in patients with GBS.
Conclusions:
This retrospective study is the first to demonstrate a relationship between the CSF protein level and the electrophysiologic abnormalities that accompany GBS.
