Adipose Derived Regenerative Cell Therapy for Treating a Diabetic Wound: A Case Report

Area of Science:

• Regenerative Medicine
• Wound Healing
• Diabetic Complications

Background:

• Diabetic foot ulcers represent a significant clinical challenge.
• Adipose-derived regenerative cells (ADRC) show potential in wound healing.
• This study reports the first successful ADRC application for a diabetic foot wound.

Purpose of the Study:

• To evaluate the efficacy of autologous adipose-derived regenerative cells (ADRC) therapy in treating a severe diabetic foot wound.
• To document the application and outcomes of ADRC therapy in a patient with resistant diabetic ulcers.

Main Methods:

• A patient with a necrotic diabetic foot wound underwent debridement and Chopart's amputation.
• Post-operative heel and incision site ulcers were treated with autologous ADRC-enriched fat grafting.
• ADRCs were generated using the Celusion System and applied to the wound bed and edges.

Main Results:

• Accelerated wound healing was observed post-ADRC treatment.
• Complete ulcer healing was achieved within 4 weeks.
• The ADRC therapy facilitated the restoration of deficient glabrous tissue.

Conclusions:

• ADRC therapy is a promising new treatment for diabetic foot wounds.
• This case highlights the potential of regenerative cell therapy in managing complex diabetic ulcers.
• Further research is warranted to explore ADRC therapy's broader application in wound management.