Related Experiment Video
Updated: Mar 30, 2026

A Mouse Model for Laser-induced Choroidal Neovascularization
Published on: December 27, 2015
CHOROIDAL NEOVASCULARIZATION SECONDARY TO ALEXANDRITE LASER EXPOSURE
Rui Wang1, Charles C Wykoff, Lynsey Christie
1*Retina Consultants of Houston, Houston, Texas; and †Blanton Eye Institute, Houston Methodist Hospital & Weill Cornell Medical College, Houston, Texas.
Purpose:
To report macular photic trauma after accidental occupational exposure to a 750-nm Alexandrite laser and management of secondary choroidal neovascularization.
Methods:
Institutional review board-approved retrospective case report.
Results:
A 30-year-old woman presented with immediate vision loss in her left eye after direct inadvertent exposure to a single discharge from an occupational 750-nm Alexandrite laser used for laser hair removal. Baseline Snellen visual acuity was 20/40 in the involved left eye. One week after the initial exposure, the patient experienced subjective visual decline to 20/50, was treated with oral prednisone, and then developed a subretinal hemorrhage (SRH) in the setting of choroidal neovascularization 2 weeks later, or 3 weeks after initial trauma. The patient subsequently received 5 intravitreal ranibizumab injections over 25 weeks with resolution of the SRH. Final visual acuity was 20/50.
Conclusion:
The present case documents development and management of subretinal hemorrhage associated with choroidal neovascularization following macular photic trauma after accidental occupational to a 750-nm Alexandrite laser.
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