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Updated: Mar 30, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

Published on: January 13, 2017

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Stereocontrol within polyketide assembly lines.

Adrian T Keatinge-Clay1

  • 1Department of Molecular Biosciences, The University of Texas at Austin, 2506 Speedway Stop A5000, Austin, TX 78712, USA. adriankc@utexas.edu and Department of Chemistry, The University of Texas at Austin, 105 E 24th St. Stop A5300, Austin, TX 78712, USA.

Natural Product Reports
|November 20, 2015
PubMed
Summary

This study examines how enzymes create stereocenters in polyketide natural products. Atomic-resolution models reveal the mechanisms of key enzymes involved in this complex biosynthetic process.

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