Inferring Disease Associated Phosphorylation Sites via Random Walk on Multi-Layer Heterogeneous Network

As protein phosphorylation plays an important role in numerous cellular processes, many studies have been undertaken to analyze phosphorylation-related activities for drug design and disease treatment. However, although progresses have been made in illustrating the relationship between phosphorylation and diseases, no existing method focuses on disease-associated phosphorylation sites prediction. In this work, we proposed a multi-layer heterogeneous network model that makes use of the kinase information to infer disease-phosphorylation site relationship and implemented random walk on the heterogeneous network. Experimental results reveal that multi-layer heterogeneous network model with kinase layer is superior in inferring disease-phosphorylation site relationship when comparing with existing random walk model and common used classification methods.